Following are the very first media reports about someone being Cured of AIDS
Ironically, usually the scientific studies are published first, followed by mainstream media. In the case of “the Berlin Patient” (Timothy Ray Brown) being the first person in the world cured of HIV, it was the opposite.
The originally study written by Dr. Gero Huetter (Timothy’s doctor and the man who came up with the brilliant idea for a cure for AIDS), was rejected outright by the New England Journal of Medicine. In essence, they didn’t believe Dr. Huetter. They said that they would reconsider if Dr. Huetter made some significant changes. Dr. Huetter refused saying, there is nothing wrong with the study, it is perfect as it has been written and presented.
It wasn’t until the Wall Street Journal wrote about Dr. Huetter’s study which was published on November 7,2008, which became huge news world wide. It was only then that the New England Journal of Medicine reconsidered and then published Dr. Huetter’s study on February 12, 2009 – more than 4 months later. Exactly as he presented it the first time, not a single world was changed.
Transplanting Hope: Stem Cell Experiment Raises Eyebrows at CROI 2008
by David Evans
Not every remarkable HIV treatment discovery makes the front page of the morning papers. Take, for example, a single-patient study presented at the 15th annual Conference on Retroviruses and Opportunistic Infections (CROI) in Boston that went largely unnoticed by news outlets but is now generating excitement among activists and researchers.
The intriguing study involves an HIV-positive German man with leukemia who has regrown a new immune system after receiving a stem cell transplant and has since kept his viral load undetectable. In fact, sensitive tests have been unable to detect the virus in the patient’s blood or tissues. According to the CROI report, presented by Gero Hütter, MD, of the Medical University of Berlin and his colleagues, the key to the transplant’s success was the stem cells provided by a donor whose immune system was genetically resistant to HIV infection. Read more>>
First Media Report that a German AIDS Patient is Cured
Reports from German press conference regarding the Berlin Patient
November 4, 2008
A Doctor, a Mutation and a Potential Cure for AIDS
November 7, 2008
Wall Street Journal
By Mark Shoofs
The startling case of an AIDS patient who underwent a bone marrow transplant to treat leukemia is stirring new hope that gene-therapy strategies on the far edges of AIDS research might someday cure the disease.
The patient, a 42-year-old American living in Berlin, is still recovering from his leukemia therapy, but he appears to have won his battle with AIDS. Doctors have not been able to detect the virus in his blood for more than 600 days, despite his having ceased all conventional AIDS medication. Normally when a patient stops taking AIDS drugs, the virus stampedes through the body within weeks, or days. Read more>>
Rare Treatment is Reported to be a Cure for AIDS Patient
New York Times
By Donald G. McNeil, Jr.
Doctors in Berlin are reporting that they cured a man o f AIDS by giving him transplanted blood stem cells from a person naturally resistant to the virus. But while the case has novel medical implications, experts say it will be of little immediate use in treating AIDS. Top American researchers called the treatment unthinkable for the millions infected in Africa and impractical even for insured patients in top research hospitals.
“It’s very nice, and it’s not even surprising,” said Dr. Anthony S. Fauci director of the National Institute of Allergy and Infectious Diseases. “But it’s just off the table of practicality.” The patient, a 42-year-old American resident in Germany, also has leukemia, which justified the high risk of a stem-cell transplant. Such transplants require wiping out a patient’s immune system, including bone marrow, with radiation and drugs; 10 to 30 percent of those getting them die. “Frankly, I’d rather take the medicine,” said Dr. Robert C. Gallo, director of the Institute of Human Virology at the University of Maryland School of Medicine, referring to antiretroviral drugs. Read more>>
Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation
New England Journal of Medicine: 360:692-698, DOI: 10.1056/NEJMoa0802905
Gero Hütter, M.D., Daniel Nowak, M.D., Maximilian Mossner, B.S., Susanne Ganepola, M.D., Arne Müßig, M.D., Kristina Allers, Ph.D., Thomas Schneider, M.D., Ph.D., Jörg Hofmann, Ph.D., Claudia Kücherer, M.D., Olga Blau, M.D., Igor W. Blau, M.D., Wolf K. Hofmann, M.D., and Eckhard Thiel, M.D.
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection.
The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection. Read more>>
Stern Magazine Germany
Please note: This article is written in German
This is the first interview with Timothy Ray Brown who came out as the Berlin Patient while still living in Germany.
Timothy Ray Brown gilt als der erste Mensch, der vom Aids-Erreger HIV geheilt wurde. Dabei verdankt er seine Rettung einem tragischen Zufall. Im stern erzählt er erstmals von seinem schweren Weg. Read more >>
Patient No More
by Regan Hofmann
Timothy Brown-a.k.a. “the Berlin Patient”-is the Man Who Once Had HIV. Recovered from a deadly form of leukemia and now virus-free, Brown embodies the hopes of scientists and millions of people living with the virus. Brown’s road to a cure is unlikely to be traveled by others. But his journey provides critical proof of a concept that just may lead to the end of AIDS-by offering clues for how to develop a safe, affordable cure for all. To walk past Timothy Brown on the street, you’d hardly know that his body contains secrets capable of ending one of the worst plagues in recorded human history. But Brown, the man known as “the Berlin Patient,” is arguably scientific proof that we can cure AIDS. Read more >>
Sangamo’s Bet Against AIDS: Gene Therapy
By Rob Waters
Timothy Brown may be the only person cured of AIDS. Brown, who lives in San Francisco, in 2007 received a stem-cell transplant in Berlin that transferred genetic material to him from one of the up to 2 percent of humans with a natural immunity to the disease. He has been off treatment since then, and no traces of the AIDS virus have been found in his body, says his hematologist, Gero Hütter, now with the German Red Cross in Mannheim. His case has encouraged tiny Sangamo BioSciences (SGMO) to develop a new form of gene therapy that could offer others the same result. Read more >>
New Hope of a Cure for AIDS
New York Times
By Andrew Pollack
Medical researchers are again in pursuit of a goal they had all but abandoned: a cure for AIDS. Until recently, the possibility seemed little more than wishful thinking. But the experiences of two patients now suggest to many scientists that it may be achievable. One man, the so-called Berlin patient, apparently has cleared his H.I.V. infection, albeit by arduous bone marrow transplants. Read more >>